Complex pathologies in mother, child, and reproductive medicine

Tipologia: Malattie Infettive

Principal Investigator: Spinillo

Co Principal Investigator: Nappi

The role and implication of minimally invasive technology in gynecological field for benign and malignant diseases;
the role of placental lesions in the obstetrics outcomes with particular attention to preterm newborn the correlation between autoimmune disease in the pregnancy outcomes (collaboration with rheumatology and endocrinology;
new strategy for medical treatment in gynecological malignancies;
nanotechnology applied to endometriosis and gynecological field;
immunology and immunophatology of HPV infection in the CIN development;
investigation of genetics of gynecological cancers, especially endometrial and ovarian cancer;
investigation on vertical infection and their role in maternal and fetal outcomes.

Gardella B., Dominoni M., Caporali C., Cesari S., Fiandrino G., Longo S., De Vito G.B., Naboni C., Tonduti D., Perotti G., Orcesi S., Spinillo A. Placental features of fetal vascular malperfusion and infant neurodevelopmental outcomes at 2 years of age in severe fetal growth restriction. American Journal of Obstetrics & Gynecology, 2021;
Revello M.G., Lazzarotto T., Guerra B., Spinillo A., Ferrazzi E., Kustermann A., Guaschino S., Vergani P., Todros T., Frusca T., Arossa A., Furione M., Rognoni V., Rizzo N., Gabrielli L., Klersy C., Gerna G., CHIP Study Group. A randomized trial of hyperimmune globulin to prevent congenital cytomegalovirus. The New England Journal of Medicine, 2014;
Spinillo A., Gardella B., Chiesa A., Cesari S., Alberizzi P., Silini E.M. Diagnostic accuracy of colposcopy in relation to human papillomavirus genotypes and multiple infection. Gynecologic Oncology, 2014;
Spinillo A., Dominoni M., Boschi A.C., Cesari S., Fiandrino G., Gardella B. The relationship of human papillomavirus infection with endocervical glandular involvement on cone specimens in women with cervical intraepithelial neoplasia. Gynecologic Oncology, 2020;
Spinillo A., Beneventi F., Caporali R., Ramoni V., Montecucco C. Undifferentiated connective tissue diseases and adverse pregnancy outcomes. An undervalued association? American Journal of Reproductive Immunology, 2017.

Endogold project, RC “HPV Immunological markers of cervical persistent infection and oncogenesis: HPVIMMUNO study”.

ULTRAMIS study group (international Collaboration with PI Prof. Ignacio Zapardiel, Madrid, Spain);
VULCAN study group (International Collaboration with PI Prof. Ignacio Zapardiel, Madrid, Spain);
SARCUT study (international Collaboration with PI Prof. Ignacio Zapardiel, Madrid, Spain);
Collaboration with Ospedale di Ancona, Prof. Andrea Ciavattini, Ancona, Italy, for HPV infection and low genital tract diseases;
Collaboration with dot. Alessandro Borghesi, OSM, and the laboratory of Zurigo, Switzerland for the research on GWAS in pregnancy and newborns;
Endogold (national collaboration with PI Prof. Simone Ferrero, Genova, Italy);
RC HPV IMMUNO (PI Prof. Barbara Gardella).