Innovation in Immunoreactive diseases

Tipologia: Immunologia

Principal Investigator: Di Sabatino

Mucosal immunology of gastrointestinal diseases (autoimmune gastritis, coeliac disease, inflammatory bowel disease);
clinical features, natural history, and oncogenesis of gastrointestinal diseases (autoimmune gastritis, coeliac disease, inflammatory bowel disease
onco - and lymphomagenesis in gastrointestinal diseases;
allergic and eosinophilic disorders;
platelet and coagulation disorders;
immunotherapy side effects;
multimorbidity and clinical complexity.

Lenti M.V., Luu S., Carsetti R., Osier F., Ogwang R., Nnodu O.E., Wiedermann U., Spencer J., Locatelli F., Corazza G.R., Di Sabatino A. Asplenia and spleen hypofunction. Nature Reviews Disease Primers, 2022;
Carloni S., Bertocchi A., Mancinelli S., Bellini M., Erreni M., Borreca A., Braga D., Giugliano S., Mozzarelli A.M., Manganaro D., Fernandez Perez D., Colombo F., Di Sabatino A., Pasini D., Penna G., Matteoli M., Lodato S., Rescigno M. Identification of a choroid plexus vascular barrier closing during intestinal inflammation. Science, 2021;
Biancheri P., Brezski R.J., Di Sabatino A., Greenplate A.R., Soring K.L., Corazza G.R., Kok K.B., Rovedatti L., Vossenkämper A., Ahmad N., Snoek S.A., Vermeire S., Rutgeerts P., Jordan R.E., MacDonald T.T. Proteolytic cleavage and loss of function of biologic agents that neutralize tumor necrosis factor in the mucosa of patients with inflammatory bowel disease. Gastroenterology, 2015;
Monteleone G., Neurath M.F., Ardizzone S., Di Sabatino A., Fantini M.C., Castiglione F., Scribano M.L., Armuzzi A., Caprioli F., Sturniolo G.C., Rogai F., Vecchi M., Atreya R., Bossa F., Onali S., Fichera M., Corazza G.R., Biancone L., Savarino V., Pica R., Orlando A., Pallone F.. Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease. The New England Journal of Medicine, 2015;
Spadoni I., Zagato E., Bertocchi A., Paolinelli R., Hot E., Di Sabatino A., Caprioli F., Bottiglieri L., Oldani A., Viale G., Penna G., Dejana E., Rescigno M. A gut-vascular barrier controls the systemic dissemination of bacteria. Science, 2015.