Research advances in vascular diseases and cardiomyopathies - Research unit

Main research topics in heart failure: Risk stratification and and drug response - Pathophysiological mechanisms underlying new therapies - Role of heart CMR in etiologic diagnosis of cardiomyopathies - Cliniucam and prognostic significance of functional tricuspid regurgitation. Reference center for randomized controlled clinical trials in heart failure with reduced or preserved EF.

Main research topics in pulmonary arterial hypertension: Genetics and pharmacogenetics of pulmonary arterial hypertension - Role of echocardiography in prognostic stratification - New prognostic biomarkers - Role of inflammation in the etiopathogenesis of PAH vasculopathy. Reference center for randomized controlled clinical trials in pulmonary arterial hypertension. 

• Ghio S., Klersy C., Corsico A., Gamba S.L., Monterosso C., Masiglat J., Borrelli E., Scelsi L., Greco A., Piloni D., Visconti L.O., D'Armini A.M. Risk stratification in patients with residual pulmonary hypertension after pulmonary endarterectomy. International Journal of Cardiology, 2021;
• Ghio S., Crimi G., Houston B., Montalto C., Garascia A., Boffini M., Temporelli P.L., La Rovere M.T., Pacileo G., Panneerselvam K., Santolamazza C., D'angelo L., Moschella M., Scelsi L., Marro M., Masarone D., Ameri P., Rinaldi M., Guazzi M., D'alto M., Tedford R.J. Nonresponse to Acute Vasodilator Challenge and Prognosis in Heart Failure With Pulmonary Hypertension. Journal of Cardiac Failure, 2021;
• Guazzi M., Ghio S., Adir Y. Pulmonary Hypertension in HFpEF and HFrEF: JACC Review Topic of the Week. JJournal of the American College of Cardiology, 2020; 
• Ghio S., Mercurio V., Fortuni F., Forfia P.R., Gall H., Ghofrani A., Mathai S.C., Mazurek J.A., Mukherjee M., Richter M., Scelsi L., Hassoun P.M., Tello K. A comprehensive echocardiographic method for risk stratification in pulmonary arterial hypertension. European Respiratory Journal, 2020; 
• Ghio S., Crimi G., Guida S., Valentini A., Celentano A., Pin M., Raineri C., Turco A., Scelsi L., Oltrona Visconti L., Naeije R., D'Armini A.M. Magnetic resonance imaging of pulmonary arterial compliance after pulmonary endarterectomy. European Respiratory Journal, 2020.

Echocardiographic equipments and workstation for offline analysis; right heart cath lab;  availability to CMR equipments. 

• Progetto finanziato da Min Salute: PNRR-POC-2022-12376518 
• Ricerca Corrente Policlinico San Matteo 2022 n. 0025223/22

• IPHNET Italian pulmonary hypertension network
• GO DEEP international registry
• PAH-CON international consortium for genetic studies