Research Unit

Innovation in Immunoreactive diseases - Research unit

GROUP LEADER

Prof. DI SABATINO Antonio

CURRICULUM VITAE GROUP LEADER

CV Prof. Di Sabatino Antonio

SPECIFIC ROLE

Coordination of the Unit's research activities.

GROUP MEMBERS
Aronico N, Barozzi S, Bergamaschi G, Bertolino G, Betti E, Bianchi PI, Bozzi V, Brera A, Costanzo F, Delliponti M, Derosa G, Di Stefano M, Lenti MV, Lovati E, Lucotti P, Martignoni A, Melazzini F, Mengoli C, Miceli E, Mugellini A, Muggia C, Palumbo I, Pecci A, Pieresca C, Preti PS, Prinzi N, Russo M, Rossi CM, Savioli G, Staniscia A.

RESEARCH PROJECTS
- Mucosal immunology of gastrointestinal diseases (autoimmune gastritis, coeliac disease, inflammatory bowel disease);
- onco - and lymphomagenesis in gastrointestinal diseases;
- allergic and eosinophilic disorders;
- platelet and coagulation disorders;
- immunotherapy side effects;
- multimorbidity and clinical complexity.
5 BEST PAPERS
- Lenti M.V., Luu S., Carsetti R., Osier F., Ogwang R., Nnodu O.E., Wiedermann U., Spencer J., Locatelli F., Corazza G.R., Di Sabatino A. Asplenia and spleen hypofunction. Nature Reviews Disease Primers, 2022;
- Carloni S., Bertocchi A., Mancinelli S., Bellini M., Erreni M., Borreca A., Braga D., Giugliano S., Mozzarelli A.M., Manganaro D., Fernandez Perez D., Colombo F., Di Sabatino A., Pasini D., Penna G., Matteoli M., Lodato S., Rescigno M. Identification of a choroid plexus vascular barrier closing during intestinal inflammation. Science, 2021;
- Biancheri P., Brezski R.J., Di Sabatino A., Greenplate A.R., Soring K.L., Corazza G.R., Kok K.B., Rovedatti L., Vossenkämper A., Ahmad N., Snoek S.A., Vermeire S., Rutgeerts P., Jordan R.E., MacDonald T.T. Proteolytic cleavage and loss of function of biologic agents that neutralize tumor necrosis factor in the mucosa of patients with inflammatory bowel disease. Gastroenterology, 2015;
- Monteleone G., Neurath M.F., Ardizzone S., Di Sabatino A., Fantini M.C., Castiglione F., Scribano M.L., Armuzzi A., Caprioli F., Sturniolo G.C., Rogai F., Vecchi M., Atreya R., Bossa F., Onali S., Fichera M., Corazza G.R., Biancone L., Savarino V., Pica R., Orlando A., Pallone F.. Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease. The New England Journal of Medicine, 2015;
- Spadoni I., Zagato E., Bertocchi A., Paolinelli R., Hot E., Di Sabatino A., Caprioli F., Bottiglieri L., Oldani A., Viale G., Penna G., Dejana E., Rescigno M. A gut-vascular barrier controls the systemic dissemination of bacteria. Science, 2015.
AVAILABLE TECHNOLOGY
- Cell isolation and culture;
- organ culture;
- ELISA;
- PCR;
- flow cytometry;
- immunohistochemistry;
- immunofluorescence;
- Western blotting;
- in situ hybridization.
RUNNING FUNDS

Clinical trials; Aging network; IRCCS research projects on autoimmune gastritis; clinical complexity; checkpoint inhibitor-induced colitis; and small bowel carcinoma; PRIN (University of Pavia).
NATIONAL AND INTERNATIONAL STRATEGIC COLLABORATIONS

Royal Free Hospital (UCL, London, UK); Leeds St. James’s University Hospital (UK); University Hospital of Cork (IE); University of New South Wales, Sidney (AUS).