Renal diseases and transplantation - Research unit

• Cell therapy with Mesenchymal Stromal Cells (MSC) and/or with Extracellular Vesicles derived from MSC (EV) in in vitro model and in ex vivo and in vivo animal (rat and pig) models of renal diseases and transplantation.
• Graft conditioning with MSC, EV and experimental drugs in animal and human models of marginal organs transplantation (DCD/ECD). 
• New drug delivery strategies in organ conditioning before transplantation.
• Extracorporeal photopheresis (ECP) innovative treatment in transplanted patients with chronic renal antibody rejection and transcriptomics studies on the mechanisms underlying the ECP therapeutic effect through Nanostring technology.
• miRNA profile to evaluate the cancer risk in transplanted patients.
• Studies on humoral and cellular immune response against virus (CMV, EBV, VZV, SARS-CoV2) and predictive markers of the bacterial/viral infections risk in transplanted and uremic patients
• Cross-talk kidney-gut in dialysis patients: Impact of dialysis biocompatibility and microbiome variation on immune/inflammatory state and survival of uremic patients.

• Rampino T., Gregorini M., Germinario G., Pattonieri E.F., Erasmi F., Grignano M.A., Bruno S., Alomari E., Bettati S., Asti A. Extracellular Vesicles Derived from Mesenchymal Stromal Cells Delivered during Hypothermic Oxygenated Machine Perfusion Repair Ischemic/Reperfusion Damage of Kidneys from Extended Criteria Donors. Biology, 2022;

• Rampino T., Gregorini M., Germinario G., Pattonieri E.F., Erasmi F., Grignano M.A., Bruno S., Alomari E., Bettati S., Asti A., Ramus M., De Amici M., Testa G., Bruno S., Ceccarelli G., Serpieri N., Libetta C., Sepe V., Blasevich F., Odaldi F., Maroni L., Vasuri F., La Manna G., Ravaioli M. Extracellular Vesicles Derived from Mesenchymal Stromal Cells Delivered during Hypothermic Oxygenated Machine Perfusion Repair Ischemic/Reperfusion Damage of Kidneys from Extended Criteria Donors. Biology (Basel), 2022;

• Berney T., Bellini M.I., Montserrat N., Naesens M., Neyens T., Schneeberger S. Reflecting on an Intense Year for Transplant International. Transplant International, 2022;

• Gregorini M., Del Fante C., Pattonieri E.F., Avanzini M.A., Grignano M.A., Cassaniti I., Baldanti F., Comolli G., Nocco A., Ramondetta M., Viarengo G., Sepe V., Libetta C., Klersy C., Perotti C., Rampino T. Photopheresis Abates the Anti-HLA Antibody Titer and Renal Failure Progression in Chronic Antibody-Mediated Rejection. Biology (Basel), 2021;

• Gregorini M., Maccario R., Avanzini M.A., Corradetti V., Moretta A., Libetta C., Esposito P., Bosio F., Dal Canton A., Rampino T. Antineutrophil cytoplasmic antibody-associated renal vasculitis treated with autologous mesenchymal stromal cells: evaluation of the contribution of immune-mediated mechanisms. Mayo Clinic Proceedings, 2013.

 Nanostring technology ;Nanosight technology; Molecular, cellular and immune-histological technologies; organ perfusion technology.

IRCCS Fondazione Policlinico San Matteo di Pavia; Pharmaceutics societies.

University of Pavia; University of Genoa; University of Turin; University of Naples; University of Bari; Policlinico Sant’Orsola Malpighi of Bologna; University of Texas; University of Columbia (USA).