Biomarkers - Research unit

• TOTAL PROCESS TESTING
• PATIENT CENTERED MEDICINE
• CLINICAL GOVERNANCE
• TOTAL QUALITY MANAGEMENT

Reducing Diagnosis Uncertainty with support of clinical laboratory 
For Patients: insufficient awareness of diagnostic reasoning
For Clinicians: incomplete science and technology knowledge – evidence based laboratory medicine 

Active Research projects include:

• Development, evaluation and implementation in clinical practice of disease biomarkers
• Mass-Spectrometry Analysis of Metabolites, Drugs of Abuse, Therapeutic Drug Monitoring
• Quantitative Biomarkers, Digital Imaging in Serological Autoimmune Disease – including Telepathology Network
• Standardization and Metrology for laboratory data comparability 

• De Gregori S., De Silvestri A., Cattadori B., Rapagnani A., Albertini R., Novello E., Concardi M., Arbustini E., Pellegrini C. Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy in Heart Transplantation: New Strategies and Preliminary Results in Endomyocardial Biopsies. Pharmaceutics, 2022;
• Valli A., Ferretti V.V., Klersy C., Lonati D., Giardini I., Papa P. Effectiveness of a Reliable Toxicological Analysis for a Correct Diagnosis of Acute Intoxication in Pediatrics: 2-year experience of an  analytical Toxicological Laboratory. Pediatric Emergency Care, 2022;
• Basset M., Milani P., Ferretti V.V., Nuvolone M., Foli A., Benigna F., Nanci M., Bozzola M., Ripepi J., Sesta M., Russo F., Bosoni T., Klersy C., Albertini R., Merlini G., Palladini G. Prospective Urinary Albumin/Creatinine Ratio for diagnosis, staging and organ response assessment in renal AL amyloidosis: results form a large cohort of patients. Clinical Chemistry and Laboratory Medicine, 2022;
• Garofoli F., Ciardelli L., Angelini M., Gentile R., Mazzucchelli I., Tinelli C., Bollani L., Tzialla C. The role of immature platelet fraction in fluu-term and preterm infants: italian data of a promising clinical biomarker in neonates. International Journal of Laboratory Hematology, 2020;
• Bozzalla-Cassione E., Zanframundo G., Biglia A., Bellis E., Bozzini S., Codullo V., Vertui V., Alpini C., Valentini A., Preda L., Montecucco C., Meloni F., Cavagna L. Anti-Ro52 antibodies positivity in antisynthetase syndrome: a single centre choort study. Clinical and Experimental Rheumatology, 2022.

• High throughput chemistry and immunochemistry analyzers HPLC with various detectors, LC-MS/MS
• Optical and immunofluorescence microscopes equipped with digital imaging device and software
• Instruments for serum proteins analysis
• Specialistic Coagulation Testing
• Radioimmuneassay facility

Institute of Biochemistry, University of Pavia, Prof A. Rossi –  Centro di Riferimento Regionale per il Coordinamento della Attività di Laboratorio, Milano – For Toxicology Laboratory: Istituto Superiore di Sanità e Centro Nazionale Antiveleni.