In our group basic and clinical research are coupled, aiming at translating deeper understanding of disease mechanisms in better patients’ care, while innovative laboratory research often stems from attentive clinical observation of patients. Our Unit coordinates clinical studies and national and international disease registries and research consortia on systemic amyloidoses.
Our research interests are manifold: (I) understanding the molecular mechanisms of systemic amyloidoses, through multi-OMICs approaches, development of pre-clinical models and clinical investigations; (II) developing molecular and imaging tools for accurate and early diagnosis, and patients monitoring; (III) studying biochemical and imaging tools for staging and monitoring the disease in individual patients and in the design of clinical trials; (IV) developing and testing more effective, targeted, and safe therapeutic approaches.
- Stephan A. Kaeser #, Stephanie A. Schultz #, Anna Hofmann #, Lisa M. Häsler, Ying Xu, Marius Lambert, Ulrike Obermüller, Kathrin Brockmann, Johan Bijzet, Hans Nienhuis*, Mario Nuvolone, Laura Obici, Giovanni Palladini*, Ute Hegenbart, Stefan O. Schönland*, Mathias Jucker*. Blood phosphorylated Tau elevation as a biomarker in immunoglobulin light chain and transthyretin amyloidosis. Nature Medicine, 2026.
- Milani P, Sanna GD, Bellofiore C, Nuvolone M, Basset M, Mussinelli R, Mazzini G, Nanci M, Ciardo M, Caminito S, Ghazi Esfahani M, Sadrzadeh M, Fogliani A, Benigna F, Guida G, Salinaro F, Bosoni T, Barassi A, Foli A, Albertini R, Perlini S, Merlini G, Palladini G. Diagnostic Performance of the New Free Light Chain Ratio in Systemic Amyloidosis. JACC CardioOncol. 2025 Oct;7(6):751-759. doi: 10.1016/j.jaccao.2025.07.012. Epub 2025 Sep 11. PMID: 40938239.
- Palladini G, Schönland S, Merlini G, Milani P, Jaccard A, Bridoux F, Dimopoulos MA, Ravichandran S, Hegenbart U, Roeloffzen W, Cibeira MT, Agis H, Minnema MC, Bergantim R, Hájek R, João C, Leonidakis A, Cheliotis G, Sonneveld P, Kastritis E, Wechalekar A. The management of light chain (AL) amyloidosis in Europe: clinical characteristics, treatment patterns, and efficacy outcomes between 2004 and 2018. Blood Cancer J. 2023 Jan 25;13(1):19. doi: 10.1038/s41408-023-00789-8. PMID: 36697388.
- Kastritis E, Palladini G, Minnema MC, Wechalekar AD, Jaccard A, Lee HC, Sanchorawala V, Gibbs S, Mollee P, Venner CP, Lu J, Schönland S, Gatt ME, Suzuki K, Kim K, Cibeira MT, Beksac M, Libby E, Valent J, Hungria V, Wong SW, Rosenzweig M, Bumma N, Huart A, Dimopoulos MA, Bhutani D, Waxman AJ, Goodman SA, Zonder JA, Lam S, Song K, Hansen T, Manier S, Roeloffzen W, Jamroziak K, Kwok F, Shimazaki C, Kim JS, Crusoe E, Ahmadi T, Tran N, Qin X, Vasey SY, Tromp B, Schecter JM, Weiss BM, Zhuang SH, Vermeulen J, Merlini G, Comenzo RL; ANDROMEDA Trial Investigators. Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis. N Engl J Med. 2021 Jul 1;385(1):46-58. doi: 10.1056/NEJMoa2028631. PMID: 34192431.
- Kastritis E, Leleu X, Arnulf B, Zamagni E, Cibeira MT, Kwok F, Mollee P, Hájek R, Moreau P, Jaccard A, Schönland SO, Filshie R, Nicolas-Virelizier E, Augustson B, Mateos MV, Wechalekar A, Hachulla E, Milani P, Dimopoulos MA, Fermand JP, Foli A, Gavriatopoulou M, Klersy C, Palumbo A, Sonneveld P, Johnsen HE, Merlini G, Palladini G. Bortezomib, Melphalan, and Dexamethasone for Light-Chain Amyloidosis. J Clin Oncol. 2020 Oct 1;38(28):3252-3260. doi: 10.1200/JCO.20.01285. Epub 2020 Jul 30. PMID: 32730181.
The main research methodologies employed include mass spectrometry, next-generation sequencing, next-generation flow cytometry, primary cell cultures, pharmacological studies, observational and interventional clinical studies.
- Single Molecule Real-Time Sequencing of M proteins (SMaRT M-Seq): from the elucidation of disease mechanisms to a personalized medicine approach for AL amyloidosis and other monoclonal gammopathies (RC Palladini);
- PNRR Promoting Diagnosis and management of AL in Italy (ProDigALIty) (Ministero Palladini);
- Bonding molecular genotyping and phenotyping to outcome measures in AL amyloidosis: A EUropean REgistry and sample sharing networK to promote the diagnosis and management of light chain Amyloidosis, EUREKA (FRRB Palladini);
- Investigating the pathogenic role of N-glycosylation in AL amyloidosis: molecular bases, diagnosis, and treatment (Cariplo Nevone);
- NatiOnal referral cenTer rEgistry of transthyretin amyloid cardiomyopathy (ATTR) patients on tafamidis: real world registry (NOTE-ATTR) (Milani, università);
- The International Transthyretin Amyloidosis Web-Network (InTrA-WebNet) (Milani, università);
- One gene, two diseases: The pathologic role of IGLV1-44 in AL amyloidosis and POEMS (Cariplo Telethon Nuvolone, Università)
- University of Catania (Italy)
- University of Bari (Italy)
- Università Campus Biomedico (Italy)
- Università La Sapienza (Italy)
- University of Milan (Italy)
- Università Vita-Salute San Raffaele (Italy)
- Università di Padova (Italy)
- University of Sassari (Italy)
- University of Navarra (Spain)
- University of Salamanca (Spain)
- University of Barcelona (Spain)
- University of Utrecht (The Netherlands)
- University of Heidelberg (Germany)
- University of Tel Aviv (Israel)
- University of Calgary (Canada)
- Mayo Clinic, Rochester (Minnesota, USA)
- Memorial Sloan Kettering (New York, USA)
- Columbia University (New York, USA)
- Harvard University (Massachusetts, USA)
- University of Applied Sciences and Arts Northwestern Switzerland (Muttenz, Switzerland)
- Institut Pasteur (Paris, France)
- Hospital Británico, in Montevideo (Uruguay)
Dott. Foli Andrea
Dott.ssa Massa Margherita
Dott.ssa Obici Laura
Dott. Milani Paolo
Dott. Nuvolone Ulisse Mario
Prof. Palladini Giovanni
GROUP MEMBERS:
Carlotta Abbà, Marco Basset, Serena Caminito, Anna Caterina Carnevale Baraglia, Simona Casarini, Giulia Chiarella, Eleonora Di Buduo, Antonella Di Gennaro, Valeria Anna Di Simone, Clarissa Granata, Maria Concetta Iacaruso, Francesca Lattarulo, Alessandro Lozza, Elone Luka, Barbara Macrì, Giulia Mazzini, , Roberta Mussinelli, Martina Nanci, Alice Nevone, Luca Ngoi, Elisa Novello, Giada Panno, Lucia Pasqualicchio, Laura Prato, Paola Rognoni, Monica Russo, Morena Salerno, Giulia Sandoli, Irene Valcozzena, Laura Verga, Annalisa Zanaboni
Ultimo aggiornamento: 20/01/2026
