Basi molecolari e Neoplasie ematologiche - Gruppo di Ricerca

The field of research includes the clinico-pathologic and immuno-molecular characterization of neoplasms of various origin, and rare diseases of different aetiology and biological behaviour.
The major area of interest concerns haematopathology: ongoing studies regard nodal and primary extranodal non-Hodgkin lymphomas (B and T), pointing out putative lymphomagenic mechanims including virus-related aetiopathogenesis (i.e. HCV). A special attention is paid to mantle cell lymphoma and primary cutaneous B and T cell lymphoma.
Among rare diseases, amyloidosis and Castleman disease are presently under investigation, also including local microenvironment and extracellular matrix.
In breast pathology, the focus is on correlation between pre-operative biotic findings and operative diagnosis and analysis of prognostic and predictive factors in breast cancer.
The main fields of interest in gastrointestinal pathology are the molecular characterization and analysis of prognostic factors in small bowel carcinomas (particularly arising in celiac disease, Crohn disease and Lynch syndrome) and in neuroendocrine neoplasms. In addition studies are proceeding regarding refractory celiac disease and its relationships with primary intestinal T-cell malignancies.

• Bonfiglio F., Bruscaggin A., Guidetti F., Terzi di Bergamo L., Faderl M., Spina V., Condoluci A., Bonomini L., Forestieri G., Koch R., Piffaretti D., Pini K., Pirosa MC., Cittone MG., Arribas A., Lucioni M., Ghilardi G., Wu W., Arcaini L., Baptista MJ., Bastidas G., Bea S., Boldorini R., Broccoli A., Buehler MM., Canzonieri V., Cascione L., Ceriani L., Cogliatti S., Corradini P., Derenzini E., Devizzi L., Dietrich S., Elia AR., Facchetti F., Gaidano G., Garcia JF., Gerber B., Ghia P., Gomes da Silva M., Gritti G., Guidetti A, Hitz F., Inghirami G., Ladetto M., Lopez-Guillermo A., Lucchini E., Maiorana A., Marasca R., Matutes E., Meignin V., Merli M., Moccia A., Mollejo M., Montalban C., Novak U., Oscier DG., Passamonti F., Piazza F., Pizzolitto S., Rambaldi A., Sabattini E., Salles G., Santambrogio E., Scarfò L., Stathis A., Stüssi G., Geyer JT., Tapia G., Tarella C., Thieblemont C., Tousseyn T., Tucci A., Vanini G., Visco C., Vitolo U., Walewska R., Zaja F., Zenz T., Zinzani PL., Khiabanian H., Calcinotto A., Bertoni F., Bhagat G., Campo E., De Leval L., Dirnhofer S., Pileri SA., Piris MA., Traverse-Glehen A., Tzankov A., Paulli M., Ponzoni M., Mazzucchelli L., Cavalli F., Zucca E., Rossi D. Genetic and phenotypic attributes of splenic marginal zone lymphoma. Blood, 2022;
• Lucioni M., Pescia C., Bonometti A., Fraticelli S., Moltrasio C., Ramponi A., Riboni R., Roccio S., Ferrario G., Arcaini L., Goteri G., Berti E., Paulli M. Double expressor and double/triple hit status among primary cutaneous diffuse large B-cell lymphoma: a comparison between leg type and not otherwise specified subtypes. Human Pathology, 2021;
• Arcaini L., Rossi D., Paulli M. Splenic marginal zone lymphoma: from genetics to management. Blood, 2016;
• Vanoli A., Guerini C., Grillo F., Klersy C., Fassan M., Arpa G., Neri G., Luinetti O., Lenti MV., Ulivi P., Tedaldi G., Furlan D., Quaquarini E., Ardizzone S., Sampietro G., Biancone L., Monteleone G., Solcia E., Sessa F., Paulli M., Adsay NV., Di Sabatino A. Poorly Cohesive Carcinoma of the Nonampullary Small Intestine: A Distinct Histologic Subtype With Prognostic Significance. The American Journal of Surgical Pathology, 2022;
• Vanoli A., Grillo F., Guerini C., Neri G., Arpa G., Klersy C., Nesi G., Giuffrida P., Sampietro G., Ardizzone S., Fociani P., Fiocca R., Latella G., Sessa F., D'Errico A., Malvi D., Mescoli C., Rugge M., Ferrero S., Poggioli G., Rizzello F., Macciomei MC., Santini D., Volta U., De Giorgio R., Caio G., Calabrò A., Ciacci C., D'Armiento M., Rizzo A., Solina G., Martino M., Tonelli F., Villanacci V., Cannizzaro R., Canzonieri V., Florena A.M., Biancone L., Monteleone G., Caronna R., Ciardi A., Elli L., Caprioli F., Vecchi M., D'Incà R., Zingone F., D'Odorico A., Lenti MV., Oreggia B., Reggiani Bonetti L., Giannone A.G., Orlandi A., Barresi V., Ciccocioppo R., Amodeo G., Biletta E., Luinetti O., Pedrazzoli P., Pietrabissa A., Corazza GR., Solcia E., Paulli M., Di Sabatino A. Prognostic Role of Mismatch Repair Status, Histotype and High-Risk Pathologic Features in Stage II Small Bowel Adenocarcinomas. Annals of Surgical Oncology, 2021.

• Automated immunostainer platform Dako Omnis Envision Flex
• NanoVue Plus Spectrophotometer
• Qubit Fluorometer
• Applied Biosystems 3130 Genetical analyzer DNA sequencer,
• Thermocycler,
• Fluorescence microscopy,
• Roche cobas z480 analyzer for Real Time PCR
• Electronic microscope Jeol JEM 1400Plus
• Illumina MiSeq (NGS, next generation sequencing).

• Ricerca Corrente  “The role of microenvironment in Castleman disease: histopathological, molecular and transcriptomic analysis with clinical correlation in a case series.” 01/01/2023 - 01/01/2025
   
• Ricerca Corrente “Clinico-pathologic and molecular study on a novel subset of mantle cell lymphoma, characterized by a MALT-type presentation and indolent behavior.” 01/04/2017 - 01/04/2024
   
• Ricerca Corrente “ Caratterizzazione clinico-patologica, immunofenotipica e molecolare dei carcinomi del piccolo intestino associati a malattia celiaca” 01/07/2014 - 01/07/2024

Gruppo Italiano Ematopatologia (GIE), Fondazione Italiana Linfomi (FIL), European Association for Haematopathology (EAHP), Mantle cell lymphoma European Network, International Extranodal Lymphoma Study Group, Small Bowel Cancer Italian Consortium, Mayo Clinic Rochester GI/Liver Pathology Section.