Fondazione IRCCS Policlinico San Matteo
N° Verde Prenotazioni (rete fissa) 800.638638 | 02 99.95.99 (da cellulare)
       
Gruppi di Ricerca

Oncoematologia di precisione - Gruppo di Ricerca

REFERENTE - GROUP LEADER
Dr. MALCOVATI Luca
CURRICULUM VITAE REFERENTE

CV Dr. Malcovati Luca

 
SPECIFIC ROLE

Coordination of the Unit's research activities.

GROUP MEMBERS
Clinical Team: Chiara Elena, Elisa Bono, Jacqueline Ferrari, Elisa Rumi, Oscar Borsani, Virginia Camilotto, Martina Boldini, F. Re;
Laboratory Team: Anna Gallì, Elisabetta Molteni, Sara Pozzi, Daniela Pietra, Cristina Picone, Marina Boni, Irene D’Ambruoso, Rita Zappatore, B. Ferrari, M. Gandossini. 

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    RESEARCH PROJECTS

    Clinical and translational research activity is focused on (i) understanding of the molecular basis of hematologic malignancies; (ii) development, transfer and implementation of precision medicine approaches; (iii) molecular and clinical characterization of pre-malignant states.
    Multi-omics and single-cell analysis are applied to characterize malignant clones, clonal hierarchies and pathways of clonal progression. The role of Microenvironment in promoting selective clonal expansion is investigated through single-cell RNA sequencing, and  3D scaffold culture models.
    The evolutionary trajectories of malignant clones are analyzed via Patient-derived models (iPSCs) and CRISPR/Cas9-based genome editing to identify actionable vulnerabilities and to develop platforms for drug screening. Novel therapeutic targets are screened as a basis for Drug development  and innovative clinical trials, including cell- and antibody-mediated immunotherapy, and inhibition through small molecules.
    Highly-sensitive, patient-specific minimal residual disease monitoring protocols are developed to guide early and pre-emptive therapeutic intervention with immunotherapy approaches.

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    5 BEST PAPERS

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    RUNNING FUNDS

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    NATIONAL AND INTERNATIONAL STRATEGIC COLLABORATIONS