Microchirurgia e rigenerazione tissutale nelle malattie del distretto testa - collo - Gruppo di Ricerca

The research projects followed are in the field of oncology, otology, rhinology and tissue regeneration/transplantology.
 

Oncology:

• electrochemotherapy in head and neck cancer;
• laser applied to robotic surgery.

Otology:

• new technologies for audiological restoration in patients with Meniere's syndrome (implantable prostheses and cochlear implants);
• Development of anatomical models with 3D printer for the placement of cochlear implants and implantable prostheses.

Rhinology:

• Treatment of patients with Rendu Osler Weber's disease;
• New devices for endoscopic nose and sinus surgery.

Tissue regeneration/transplantology:

• Scaffolds models with stem cells for the reconstruction of the upper aero digestive tract;
• Shape memory engineered tissue in minimally-invasive surgery for tissue regeneration and localized treatment;
• Development of 3D printed anatomical models (mandibular reconstruction);
• Autotransplantation in the treatment of cervical and facial neoplasms: preoperative screening and functional evaluations.

• Pisani, S.; Bertino, G.; Prina-Mello, A.; Locati, L.D.; Mauramati, S.; Genta, I.; Dorati, R.; Conti, B.; Benazzo, M. Electroporation in Head-and-Neck Cancer: An Innovative Approach with Immunotherapy and Nanotechnology Combination. Cancers 2022, 14, 5363. https://doi.org/10.3390/cancers14215363
• Pisani, S., Croce, S., Mauramati, S., Marmonti, M., Cobianchi, L., Herman, I., Dorati, R., Avanzini, M. A., Genta, I., Benazzo, M., & Conti, B. (2022). Engineered Full Thickness Electrospun Scaffold for Esophageal Tissue Regeneration: From In Vitro to In Vivo Approach. Pharmaceutics, 14(2), 252. https://doi.org/10.3390/pharmaceutics14020252
• Canzi P, Luzzi S, Carlotto E, Simoncelli A, Brondino N, Marconi S, Magnetto M, Lucifero GA, Avato I, Manfrin M, Auricchio F, Preda L, Benazzo M. Customized Cochlear Implant Positioning in a Patient With a Low- Grade Glioma: Towards the Best MRI Artifact Management. Otol Neurotol. 2022 Jul 1;43(6):e628-e634. doi: 10.1097/MAO.0000000000003532. Epub 2022 Jun 17. PMID: 35709416.
• Robotti C, Costantini G, Saggio G, Cesarini V, Calastri A, Maiorano E, Piloni D, Perrone T, Sabatini U, Ferretti VV, Cassaniti I, Baldanti F, Gravina A, Sakib A, Alessi E, Pascucci M, Casali D, Zarezadeh Z, Zoppo VD, Pisani A, Benazzo M. Machine Learning-based Voice Assessment for the Detection of Positive and Recovered COVID-19 Patients. J Voice. 2021 Nov 26:S0892-1997(21)00388-X. doi: 10.1016/j.jvoice.2021.11.004. Epub ahead of print. PMID: 34965907; PMCID: PMC8616736
• Pagella F, Pusateri A, Maiorano E, Spinozzi G, Ugolini S, Lizzio R, Mirabella R, Tinelli C, Olivieri C, Matti E. Endoscopic surgical treatment of epistaxis in hereditary haemorrhagic telangiectasia: our experience. Acta Otorhinolaryngol Ital. 2021 Feb;41(1):59-68. doi: 10.14639/0392-100X-N0915. PMID: 33746224; PMCID: PMC7982753.

Italian patent application No. 102021000019256 filed on July 20th, 2021) “METODO PER LA PRODUZIONE DI UN TESSUTO A MEMORIA DI FORMA E USI RELATIVI” Inventori: Marco Benazzo, Silvia Pisani, Maria Antonietta Avanzini (Fondazione IRCCS Policlinico San Matteo- 50%) Bice Conti, Ida Genta, Rossella Dorati (università di Pavia – 50%).

• Ricerca Corrente 08053922 “Nano-Electro-Chemo-Immuno Therapy (NECIT) to enhance head and neck cancer treatment” 01/01/2023 - 01/01/2025
• Ricerca Corrente 08053921 “3D-Hybrid Engineered Tubular Bioscaffold for Esophageal Tissue Regeneration: from in vitro to in vivo validation.” 01/07/2021- 01/07/2024

• Dipartimento di Scienze del Farmaco, Università degli studi di Pavia
• IGEA S.P.A.  https://www.igeamedical.com/en/company