Controllo infezioni multi-resistenti - Gruppo di Ricerca

The research activity on COVID 19  pandemic focused on the main clinical aspects of COVID 19 pathology by highlighting the 'early response' to the pandemic event, through the analysis of the impact of therapy in severe forms of respiratory failure, the creation  of mathematical models predictive of the spread of the pandemic and the impact of vaccines, and the caractheristic of Covid patients  admitted to Fondazione IRCCS Policlinico San Matteo.
Actually we are involved in researches on the evaluation of clinical biomarker for early diagnosis of sepsis, on the role of gut microbiota in modulating the response to chemo-free therapy in hematological malignancies and on the role of chronic inflammation in the pathogenesis of valve damage in infective endocarditis.

• • Giordano, G., Colaneri, M., Di Filippo, A., Blanchini, F., Bolzern, P., De Nicolao, G., Sacchi, P., Colaneri, P., Bruno, R. Modeling vaccination rollouts, SARS-CoV-2 variants and the requirement for non-pharmaceutical interventions in Italy (2021) Nature Medicine, 27 (6), pp. 993-998. Cited 107 times.
  • Goldman, J.D., Lye, D.C.B., Hui, D.S., Marks, K.M., Bruno, R. Remdesivir for 5 or 10 days in patients with severe covid-19 (2020) New England Journal of Medicine, 383 (19), pp. 1827-1837. Cited 873 times.
  • Colaneri, M., Seminari, E., Novati, S., Asperges, E., Biscarini, S., Piralla, A., Percivalle, E., Cassaniti, I., Baldanti, F., Bruno, R., The COVID19 IRCCS San Matteo Pavia Task Force. Severe acute respiratory syndrome coronavirus 2 RNA contamination of inanimate surfaces and virus viability in a health care emergency unit(2020) Clinical Microbiology and Infection, 26 (8), pp. 1094.e1-1094.e5. Cited 88 times.
  • Giordano, G., Blanchini, F., Bruno, R., Colaneri, P., Di Filippo, A., Di Matteo, A., Colaneri, M.Modelling the COVID-19 epidemic and implementation of population-wide interventions in Italy (2020) Nature Medicine, 26 (6), pp. 855-860. Cited 1042 times.
  • Colaneri, M., Bogliolo, L., Valsecchi, P., Sacchi, P., Zuccaro, V., Brandolino, F., Montecucco, C., Mojoli, F., Giusti, E.M., Bruno Tocilizumab for treatment of severe covid-19 patients: Preliminary results from smatteo covid19 registry (smacore) (2020) Microorganisms, 8 (5), art. no. 695,. Cited 158 times.

• One Health Basic and Translational Research Actions Addressing Unmet Needs on Emerging Infectious Diseases FONDAZIONE INF-ACT ( PNRR)
• Pan-European Response to the ImpactS of COVID-19 and future Pandemics and Epidemics – PERISCOPE” – HORIZON  2020
• Gut microbiota and microbial translocation profiling during chemo-free treatment of lymphoid malignancies as biomarkers for predicting therapeutic response and immune related adverse events”  2018-2021 – prolonged to 2024
• Evaluation of biomArkers for quick SEpsis Diagnosis - ErASED Study – Ricerca corrente 2023 – 2024
• 3Calcific aortic valve disease: a multidisciplinary approach to investigate the role of bacteria as trigger of a chronic inflammation in the pathogenesis of calcification - Ricerca corrente 2023 – 2024

• One Health Basic and Translational Research Actions Addressing Unmet Needs on Emerging Infectious Diseases FONDAZIONE INF-ACT ( PNRR)
• Hospital networking in the Lombardy Region: control of healthcare associated infections and antibiotic resistance through an advanced IT platform for microbial genomics and big data integration (H,Sacco- H. Niguarda- San Matteo - UniMi)
• “Pan-European Response to the ImpactS of COVID-19 and future Pandemics and Epidemics – PERISCOPE” – HORIZON  2020 
•  4CE-Consortium for Clinical Characterization of COVID-19 by EHR coordinato da Harvard University